The Immune System
10 Warning Signs of Primary Immune Deficiency from Immune Disease website
Is it Just an Infection from the Immune Deficiency Foundation
Our Immune System from the Immune Deficiency Foundation
General Immunology Center for Environmental Health and Safety, Southern Illinois University Carbondale
Blood Cell Deficiencies – from Bulletin for Experimental Treatment of AIDS
Understanding the Immune System National Institutes of Health, National Cancer Institute, U.S. Department of Health and Human Services, Public Health Service (pdf format)
When The Body’s Defenses Are Missing National Institute of Child Health and Human Development
How Your Immune System Works howstuffworks.com
The Patient and Family Handbook from the IDF
Immune Deficiency Conditions from The Wrong Diagnosis
SCID
Forms of SCID
OMIM Entry 300400 XSCID, X-Linked SCID
OMIM Entry 308380 INTERLEUKIN 2 RECEPTOR, GAMMA; IL2RG
OMIM Entry 102700 ADENOSINE DEAMINASE; ADA
OMIM Entry 608958 ADENOSINE DEAMINASE; ADA
OMIM Entry 600173 JANUS KINASE 3; JAK3 SCID
OMIM Entry 164050 NUCLEOSIDE PHOSPHORYLASE; NP
OMIM Entry 146661 INTERLEUKIN 7 RECEPTOR; IL7R SCID
OMIM Entry176947 ZETA-CHAIN-ASSOCIATED PROTEIN KINASE; ZAP70 SCID
OMIM Entry 600802 SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T-NEGATIVE/B-POSITIVE TYPE
OMIM Entry 209920 BARE LYMPHOCYTE SYNDROME, TYPE II
OMIM Entry 603554 OMENN SYNDROME
OMIM Entry 601457 SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE
OMIM Entry 179615 RECOMBINATION-ACTIVATING GENE 1; RAG1
OMIM Entry 179616 RECOMBINATION-ACTIVATING GENE 2; RAG2
OMIM Entry 269840 SEVERE COMBINED IMMUNODEFICIENCY, ATYPICAL
OMIM Entry 242700 IMMUNE DEFECT DUE TO ABSENCE OF THYMUS, NEZELOF SYNDROME
OMIM Entry 608971 SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-POSITIVE, NK CELL-POSITIVE
SCID Information
scidstuff A blog with SCID related news articles
Patient and Family Handbook – Severe Combined Immunodeficiency Immune Deficiency Foundation
Learning About Severe Combined Immunodeficiency (SCID) National Human Genome Research Institute’s information page on SCID
eMedicine – Severe Combined Immune Deficiency – disease description
SCID – Hope Through Research
Duke Doctors Can Now Cure Most Babies Born With Fatal Immune Disease 2/17/99 Biology section – about.com
ADAGEN Information The only enzyme replacement therapy for patients with ADA-deficient Severe Combined Immunodeficiency Disease
Candian Paediatric Suveillance Program for Severe combined immunodeficiency
RealPlayer Video: Drs. Rebecca Buckley and Jennifer Puck. Wednesday, September 20, 2000 Author/Sponsor:NIH Clinical Center Grand Rounds: Bench to Bedside Total Running Time: 00:57:22 Bandwidth: 33 Kbps. You will need RealPlayer installed to view the video. (go to site and click on “Search” use term SCID to search.)
Curing Bubble Babies, 02/25/99 Biology section – about.com
Severe Combined Immune Deficiency from kidshealth.org
Adenosine deaminase deficiency and treatment – by Christopher D. Lee (undergraduate)
Genetics Home Reference: X-linked Severe Combined Immunodeficiency
Stem Cell Transplants For Babies With Severe Combined Immunodeficiency (SCID) Reported in Science Daily January 29, 2002
SCID Kids Leading Healthy, Normal Lives 25 Years After ‘Bubble Boy DukeNews
Gene Therapy Information
Gene Therapy and Your Child kidshealth.org, general information on gene therapy
The Gene Geniuses The Guardian a UK publication
ABCNews Video: French scientists report extremely promising results from a trial procedure involving two infants with the so-called Bubble Boy disease. ABCNEWS’ Sheila MacVicar reports. You will need RealPlayerinstalled to view the video.
Gene therapy may offer release from sterile isolation for patients lacking immune systems
Real Player Video: Development of T-ALL in Two Subjects in a Gene Transfer Clinical Trail for X-SCID
ADA SCID Gene therapy: Treating the bubble babies 11/21/02 The Wellcome Trust
Applying Public Health Strategies to Primary Immunodeficiency Diseases: A Potential Approach to Genetic Disorders or PDF Version of this Article
Boy’s Cancer Prompts FDA to Halt Gene Therapy Washington Post, March 4, 2005
scidstuff Gene Therapy in the News
Journal Articles
Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency – from the The New England Journal of Medicine — February 18, 1999 — Volume 340, Number 7
Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease — Science 2000 April 28; 288: 669-672
T-cell-depleted maternal bone marrow transplantation for siblings with X-linked severe combined immunodeficiency, The Journal of Pediatrics February 1993 (Vol. 122, Issue 2, Pages 289-291)
Gene therapy for adenosine-deaminase-deficient severe combined immunodeficiency, Best Practice & Research Clinical Haematology September 2004 (Vol. 17, Issue 3, Pages 505-516)
HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR SEVERE COMBINED IMMUNODEFICIENCY DISEASE, Immunology and Allergy Clinics of North America
1 February 2000 (Vol. 20, Issue 1, Pages 207-220)
Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiency, The Journal of Allergy and Clinical Immunology October 2007 (Vol. 120, Issue 4, Pages 892-899)
PID
The Clinical Presentation Of The Primary Immunodeficiency Diseases A Primer For Physicians
Selective antipolysaccharide antibody deficiency associated with peripheral blood CD5+ B-cell predominance – Journal of Allergy and Clincal Immunology – April 1999 • Volume 103 • Number 4
Chronic Granulomatous Disease
Forest’s Omenn Syndrome Page
PIDS – A Guide For Patients and Families
The Pediatric PID Page for Families and Caregivers
Primary Immune Deficiencies Diseases – A Guide for Nurses
Bone Marrow Transplants in non-SCIDS Primary Immunodeficiency Disorders – from July/August Newsletter, KIDS Foundation of NZ.
ImmuneDisease.com by Baxter Healthcare
The ImmunoDeficiency Resource (IDR) is a Web accessible compendium of information on the immunodeficiencies. This resource includes tools for clinical, biochemical, genetic, structural and computational analyses as well as links to related information maintained by others.
Primary Immune Deficiency
Key Facts for Physicians and Patients National Institute of Allergy and Infectious Diseases –
National Institutes of Health
Primary Immunodeficiency Diseases National Institute of Allergy and Infectious Diseases –
National Institutes of Health
National Human Genome Research Institute
NHGRI Genetic, Rare and Orphan Disease Resources Online
Other Sites of Interest and Personal Home Pages:
Creutzfeldt-Jakob Disease Foundation, Inc.
National Vaccine Information Center
Lymphocyte Homing Research
A Glossary of Terms used in Allergy and Immunology
Medical Resources: Allergy, Asthma & Immunology Online
Communicable Disease Fact Sheets
Bone Marrow Transplants, A Book of Basics for Patients Presented by the BMT Newsletter, it is written from the perspective of a BMT for cancer.
Special Child Magazine
Blood Recall/Withdrawal – CJD
Younglung Email Support Listserv – a support site for Teen and Young Adults living with ANY chronic Lung Ailment.
Pediatric Interstitial Lung Disease Society – This group is for Families of Children up to the age of 21 with any form of an Interstitial Lung Disease.
Needy Meds